CD36-Mediated Lipid Accumulation and Activation of NLRP3 Inflammasome Lead to Podocyte Injury in Obesity-Related Glomerulopathy

<div>Effects of inhibiting NLRP3 by MCC950 on leptin-induced podocyte injury and IL-1<i>β</i> secretion. (a) and (b) Differentiated podocytes were incubated in medium, medium containing 15 ng/mL leptin, or medium containing both 15 ng/mL leptin and 1 <i>μ</i>M MCC950, respectively. The relative mRNA and protein expression levels of nephrin, podocin, and desmin (a) and IL-1<i>β</i> (b) of podocytes were measured by real-time quantitative PCR and Western blot assay. 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Mediators of Inflammation

fig8

Figure 8

Figure 8: CD36-Mediated Lipid Accumulation and Activation of NLRP3 Inflammasome Lead to Podocyte Injury in Obesity-Related Glomerulopathy 