CD4⁺ TSCMs in the Bone Marrow Assist in Maturation of Antibodies against Influenza in Mice

Figure 3

Homing of TSCMs to the BM. (a) Comparison of the homing index of naïve T cells and CD4⁺ TSCMs. Data are representative of three independent experiments. (b) Numbers of transferred TSCMs in the SP and BM. Data were representative of three independent experiments (). The numbers of CD45.2⁺ CD4⁺ CD44^low CD62L^high CD122^high Sca-1^high cells were shown as means ± SD, -test. , . (c) High expression of Bcl-2 in CD4⁺ TSCMs relocated in the BM. The 2 × 10⁶ CD44^low CD62L^high CD4⁺ T cells sorted from the spleen or bone marrow in C57B6/J mice were adoptively transferred to CD45.1 mice. The overlaid histogram shows the expressions of Bcl-2 of CMTPX-positive cells in BM and SP cells. Data are representative from three independent experiments and shown as means ± SD (), one-way ANOVA. , .

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