Inflammasome Genes’ Polymorphisms in Egyptian Chronic Hepatitis C Patients: Influence on Vulnerability to Infection and Response to Treatment

Table 2

SNP characteristics and population.

Gene	SNP ID	Alleles (major/minor)	Ch no/position	mRNA position	Protein position	Change in amino acid	Relative excess heterozygosity (95% confidence interval) ^a	value HWE^b
NLRP3	rs1539019	A/C	1: 247436999	—	—	Intron	0.7 (0.47-1.06)	0.118
	rs35829419	C/A	1: 247425556	2859	705	Q705K	1.8 (0.95-3.53)	0.103
	rs10754558	G/C	1: 247448734	3745	—	3UTR	0.8 (0.49-1.19)	0.298
IL-1B	rs1143629	A/G	2: 112835941	—	—	Intron	1.2 (0.77-1.75)	0.654
	rs1143634	G/A	2: 112832813	402	105	F105F	0.6 (0.4-0.97)	0.055
IL-18	rs187238	C/G	11: 112164265	—	—	Intron	0.9 (0.57-1.57)	0.976
	rs1946518	G/T	11: 112164735	—	—	Intron	0.8 (0.51-1.29)	0.483
CARD8	rs6509365	A/G	19: 48240212	—	—	Intron	0.9 (0.58-1.43)	0.81
	rs2043211	A/T	19: 48234449	541	102	C10X	0.6 (0.4-0.97)	0.055

^a2-sided -value. is considered significant. ^b-value of the exact Hardy–Weinberg equilibrium lack-of-fit test. Q: glutamine; K: lysine; F: phenylalanine; C: cysteine; X: termination.