Research Article
Inflammasome Genes’ Polymorphisms in Egyptian Chronic Hepatitis C Patients: Influence on Vulnerability to Infection and Response to Treatment
Table 5
Influence of SNPs on the degree of liver fibrosis in HCV patients.
| | Gene | SNP ID | Genotype | F1 (107) | F2 (39) | F3 (42) | value |
| | NLRP3 | rs1539019 | AA | 28 (26.2%) | 17 (43.6%) | 11 (29.4%) | 0.95 | | AC | 64 (59.8%) | 21 (53.8%) | 28 (60.4%) | | CC | 15 (14%) | 1 (2.6%) | 3 (10.2%) | | A | 120 (56.1%) | 55 (70.5%) | 50 (59.5%) | 0.08 | | C | 94 (43.9%) | 23 (29.5%) | 34 (40.5%) | | rs35829419 | CC | 93 (86.9%) | 34 (87.2%) | 34 (81%) | 0.74 | | CA | 13 (12.1%) | 5 (12.8%) | 8 (19%) | | AA | 1 (0.9%) | 0 (0%) | 0 (0%) | | C | 199 (93%) | 91 (94.8%) | 76 (90.5%) | 0.7 | | A | 15 (7%) | 5 (5.2%) | 8 (9.5) | | rs10754558 | GG | 25 (28.1%) | 9 (30%) | 5 (17.9%) | 0.7 | | GC | 47 (52.8%) | 16 (53.3%) | 15 (53.5%) | | CC | 17 (19.1%) | 5 (16.7%) | 8 (28.6%) | | G | 97 (54.5%) | 34 (56.7%) | 25 (44.6%) | 0.36 | | C | 81 (45.5%) | 26 (43.3%) | 31 (55.4%) |
| | IL-1β | rs1143629 | AA | 40 (37.4%) | 23 (59%) | 18 (42.9%) | 0.21 | | AG | 49 (45.8%) | 13 (33.3%) | 18 (42.9%) | | GG | 18 (16.8%) | 3 (7.7%) | 6 (14.3%) | | A | 129 (60.3%) | 59 (75.6%) | 54 (64.3%) | 0.52 | | G | 85 (39.7%) | 19 (24.4%) | 30 (35.7%) | | rs1143634 | GG | 55 (51.4%) | 14 (35.9%) | 21 (50.0%) | 0.4 | | GA | 43 (40.2%) | 22 (56.4%) | 16 (38.1%) | | AA | 9 (8.4%) | 3 (7.7%) | 5 (11.9%) | | G | 153 (71.5%) | 50 (64.1%) | 58 (69.1%) | 0.48 | | A | 61 (28.5%) | 28 (35.9%) | 26 (30.9%) |
| | IL-18 | rs187238 | GG | 1 (0.9%) | 3 (7.7%) | 1 (2.4%) | 0.15 | | CG | 47 (43.9%) | 17 (43.6%) | 23 (54.8%) | | CC | 59 (55.1%) | 19 (48.7%) | 18 (42.9%) | | C | 165 (77.1%) | 55 (70.5%) | 59 (70.2%) | 0.34 | | G | 49 (22.9%) | 23 (29.5%) | 25 (29.8%) | | rs1946518 | GG | 40 (37.4%) | 13 (33.3%) | 11 (26.2%) | 0.35 | | GT | 47 (43.9%) | 16 (41.0%) | 25 (59.5%) | | TT | 20 (18.7%) | 10 (25.6%) | 6 (14.3%) | | G | 127 (59.4%) | 42 (53.9%) | 47 (55.9%) | 0.67 | | T | 87 (40.7%) | 36 (46.1%) | 37 (44.1%) |
| | CARD8 | rs6509365 | GG | 11 (10.3%) | 7 (17.9%) | 8 (19.0%) | 0.5 | | AG | 52 (48.6%) | 20 (51.3%) | 20 (47.6%) | | AA | 44 (41.1%) | 12 (30.8%) | 14 (33.3%) | | A | 140 (65.4%) | 44 (56.4%) | 48 (57.1%) | 0.23 | | G | 74 (34.6%) | 34 (43.6%) | 36 (42.9%) | | rs2043211 | AA | 47 (43.9%) | 14 (35.9%) | 17 (40.5%) | 0.69 | | AT | 50 (46.7%) | 18 (46.2%) | 20 (47.6%) | | TT | 10 (9.3%) | 7 (17.9%) | 5 (11.9%) | | A | 144 (67.3%) | 46 (59%) | 54 (64.3%) | 0.42 | | T | 70 (32.7%) | 32 (41%) | 30 (35.7%) |
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Fibrosis degree was assessed using METAVIR score. The statistical analyses were conducted using the chi-square test. is considered significant. |
