Research Article
Dihydrotanshinone I Alleviates Crystalline Silica-Induced Pulmonary Inflammation by Regulation of the Th Immune Response and Inhibition of STAT1/STAT3
Figure 4
DHI modulated the Th17 immune response in a mouse model of CS-induced inflammation. The percentage of CD4+IL-17A+ Th17 cells in the HLN (a, c) and spleen (b, d) was detected by flow cytometry ( to 6 per group). (e) ELISA analysis of IL-17A levels in the BALF ( per group). (f, g) Th17 nuclear transcription factor ROR-γt expression levels in mouse lung and spleen were assayed by qRT-PCR ( to 6 per group). Data are presented as the . ; . All experiments were performed in triplicate.
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