Integrated Functional Analysis of the Nuclear Proteome of Classically and Alternatively Activated Macrophages

Figure 7

Top molecules that were differentially associated with M1 and M2 polarization of Mφ. The bar graphs show the proteins spots that were maximally and significantly changed in abundance (a–c), SNO modification (d–f), and phosphorylation (g, h) in M1 vs. M0 Mφ (a, d, g), M2 vs. M0 Mφ (b, e, h), and M2 vs. M1 Mφ (c, f). Note that a negative value for the ratio of ratio (RoR) indicates an increase in SNO modification and a positive RoR indicates decrease in SNO modification (d–f). In (g, h), data are plotted as protein spots with more than 10-fold increase or decrease in phosphorylation levels. Protein names (and spot #) are written below each category.