iNKT Cell Activation Exacerbates the Development of Huntington’s Disease in R6/2 Transgenic Mice

Figure 2

The absence of iNKT cells does not alter the development of HD in R6/2 Tg mice. (a) The survival rates of Jα18^+/− R6/2 WT, Jα18^−/− R6/2 WT, Jα18^+/− R6/2 Tg, and Jα18^−/− R6/2 Tg mice were monitored every week starting from 5 weeks of age for a total of 14 weeks. (b-c) These mice were also tested for hindlimb clasping behavior and weighed at 12 weeks of age. (d) Brains were harvested from these mice at 12 weeks of age, and their brain weights were evaluated. (e) Spleens were prepared from these mice at 12 weeks of age, and the total number of their splenocytes was evaluated. The mean (-13 in a, b, and c; in d and e; indicates the number of mice per group in the experiment) are shown (ns: not significant).

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