iNKT Cell Activation Exacerbates the Development of Huntington’s Disease in R6/2 Transgenic Mice

Figure 3

Repeated activation of iNKT cells with α-GalCer enhances the development of HD in R6/2 Tg mice. (a-c) Both R6/2 WT and Tg mice were i.p. injected with either PBS () or α-GalCer (2 μg) () once per week from 5 weeks of age for a total of 9 weeks. (a-b) These mice were also weighed and tested for hindlimb clasping behavior weekly starting from 5 weeks of age for a total of 9 weeks. (c) Brains were harvested from these mice at 9 weeks after α-GalCer injection, and their brain weights were evaluated. The mean (, and ) are shown (ns: not significant). Two-way ANOVA (genotype × treatment) showed an interaction between these two factors ().

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