Anti-TNF-α Monoclonal Antibody Therapy Improves Anemia through Downregulating Hepatocyte Hepcidin Expression in Inflammatory Bowel Disease

Figure 1

Hepcidin is increased in the sera of IBD patients and associated with disease activity, C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR), respectively. (a) Serum samples were collected from healthy control (HC, ), active CD patients (A-CD, ), CD patients in remission (R-CD, ), active UC patients (A-UC, ), and UC patients in remission (R-UC, ), and hepcidin was analyzed by ELISA. , . Data were expressed as , unpaired Student’s -tests. (b) Correlation between Crohn’s disease activity index (CDAI) and hepcidin in patients with CD (). (c) Correlation between Mayo score and hepcidin in patients with UC (). (d) Correlation between CRP and hepcidin in patients with (). (e) Correlation between CRP and hepcidin in patients with UC (). (f) Correlation between ESR and hepcidin in patients with CD (). (g) Correlation between ESR and hepcidin in patients with UC (). Correlation analysis was performed by Spearman’s correlation analysis. values are shown in each panel.

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