Altered Toll-Like Receptor Signalling in Children with Down Syndrome

Figure 2

Neutrophil and total monocyte Toll-like receptor (TLR2) and CD11b expression in response to LPS and Pam3Csk4 in children with Down syndrome (DS, ) and controls (). Values expressed as mean channel fluorescence (MFI): (a) neutrophil TLR2; (b) total monocyte TLR2 ( vs. vehicle control, vs. vehicle in the respective cohort, and vs. vehicle, LPS, and Pam3Csk4 in the respective cohort); (c) neutrophil CD11b ( vs. vehicle control, vs. vehicle in their respective cohort, and vs. vehicle and Pam3Csk4 in the respective cohort); (d) total monocyte CD11b ( vs. vehicle control, vs. vehicle in their respective cohort, vs. vehicle and Pam3Csk4 in the respective cohort, and vs. vehicle, LPS, and Pam3Csk4 in the respective cohort).

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