Role of Microbiome in Modulating Immune Responses in Cancer

Figure 1

(a) Treatment of tumor in germ-free or antibiotic-treated mice shows poor response to immune checkpoint blockers. When fecal transplant is made to these germ-free or antibiotic-treated mice from responders, the mice show improved response to the same immune checkpoint blockers. (b) Treatment of tumor in mice with normal microbiome shows improved response to immune checkpoint blockers, and the prevalent species of microbiota include Bacteroides [74], Burkholderia [74], Akkermansia muciniphila [75], Faecalibacterium [77], and Clostridiales [77].

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