Noncanonical IFN Signaling, Steroids, and STATs: A Probable Role of V-ATPase

Figure 3

Binding of eRNA to various players in gene activation provides insight into its function. DHT/AR and E2/ERα binding places eRNA at the enhancer and promoter, as these nuclear receptor systems have been shown to be present at both sites. CBP/p300 histone acetyl transferase interaction with eRNA suggests epigenetic functions, while RNA polymerase II (Pol II) is involved in transcription at both the promoter and enhancer. STAT association with eRNA has not been definitively determined yet. Determination of complexes at the promoter and enhancer is key to understanding which factors directly bind to eRNA and which bind indirectly as members of transcriptional complexes. Nuclear receptor studies suggest that eRNA plays a role in looping of the enhancer and promoter via the interactions such as those shown here.