Mediators of Inflammation

Research Article

Impact of Intensive Lifestyle Modification on Levels of Adipokines and Inflammatory Biomarkers in Metabolically Healthy Obese Women

Table 1

Parameters at baseline ( MHO participants) vs. after 2 years ( MHO participants) of lifestyle modification, according to percentage of weight loss.
Weight loss groupBaseline2 years
Age (years)<5%— 
≥5-<10%— 
≥10%— 
All 
Body weight (kg)<5%0.698
≥5-<10%0.003
≥10%<0.001
All<0.001
BMI (kg/m2)<5%0.724
≥5-<10%0.005
≥10%<0.001
All<0.001
Waist circumference (cm)<5%0.831
≥5-<10%0.002
≥10%<0.001
All<0.001
SBP/DBP (mmHg)<5%//0.285/0.302
≥5-<10%115±10/78±7/0.501/0.342
≥10%110±14/76±11/0.498/0.402
All//0.532/0.199
Glucose (mmol/l)<5%0.012
≥5-<10%0.833
≥10%0.376
All0.214
HbA1c (%)<5%0.635
≥5-<10%0.333
≥10%0.801
All0.645
Total cholesterol (mmol/l)<5%0.578
≥5-<10%4.89±0.770.098
≥10%0.478
All0.941
LDL cholesterol (mmol/l)<5%0.445
≥5-<10%0.902
≥10%0.789
All0.501
HDL cholesterol (mmol/l)<5%0.112
≥5-<10%0.584
≥10%0.897
All0.632
Triglycerides (mmol/l)<5%0.98 (0.76–1.29)0.98 (0.77–1.47)0.545
≥5-<10%0.88 (0.66–1.39)0.70 (0.62–0.99)0.003
≥10%0.93 (0.69–1.18)0.85 (0.72–1.08)0.497
All0.95 (0.75–1.27)0.89 (0.70–1.23)0.132
Group 1: weight loss <5% (baseline, ; 2nd year, ); Group 2: weight loss ≥5-<10% (baseline, ; 2nd year, ); Group 3: weight loss ≥10% (baseline, ; 2nd year, ). SBP: systolic blood pressure; DBP: diastolic blood pressure. Normal values (NV): glucose NV: 3.89-6.16; HbA1c NV: 4.0-6.0; total cholesterol NV: <5.18; LDL cholesterol NV: <3.37; HDL cholesterol NV: >1.30; triglycerides NV: <1.70.