Impact of Intensive Lifestyle Modification on Levels of Adipokines and Inflammatory Biomarkers in Metabolically Healthy Obese Women

Table 4

Adipokine and inflammatory biomarker levels at baseline vs. after 2 years of lifestyle modification, according to percentage of weight loss. MHO participants: baseline, ; 3 months, ; 1^st year, ; and 2^nd year, .

	Weight loss	Baseline	3 months	1 year	2 years	(baseline vs. 2 y)
Adiponectin (ng/ml)	<5%					0.003
	≥5-<10%					0.699
	≥10%					0.911
	All					0.039
Resistin (ng/ml)	<5%					<0.001
	≥5-<10%					0.08
	≥10%					<0.001
	All					<0.001
hsCRP (mg/l)	<5%					0.003
	≥5-<10%					0.010
	≥10%					0.097
	All					<0.001
IL-6 (pg/ml)	<5%					<0.001
	≥5-<10%					0.001
	≥10%					<0.001
	All					<0.001
TNFa (pg/ml)	<5%					0.001
	≥5-<10%					0.019
	≥10%					<0.001
	All					<0.001

Group 1: weight loss <5% (baseline: 3 months, ; 1^st year, ; and 2^nd year, ); Group 2: weight loss ≥5-<10% (baseline: 3 months, ; 1^st year, ; and 2^nd year, ); Group 3: weight loss ≥10% (baseline: 3 months, ; 1^st year, ; and 2^nd year, ). Normal values (NV): adiponectin NV: 0.8–21; resistin NV: 6.1–26.4; hsCRP NV: 0.07-8.2; IL-6 NV: 3.13–12.5; TNFa NV: <15.6.