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Mediators of Inflammation
Volume 2019, Article ID 4182015, 14 pages
Research Article

Interleukin-4 Promotes Myogenesis and Boosts Myocyte Insulin Efficacy

1Department of Biotechnology and Laboratory Science in Medicine, National Yang-Ming University, Taipei, Taiwan
2Program in Molecular Medicine, National Yang-Ming University and Academia Sinica, Taipei, Taiwan
3Department of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung, Taiwan
4Clinical Laboratory, Chung Shan Medical University Hospital, Taichung, Taiwan
5Department of Nursing, College of Nursing, Hungkuang University, Taichung, Taiwan

Correspondence should be addressed to Ming-Yuh Shiau;

Received 10 April 2019; Revised 30 June 2019; Accepted 18 July 2019; Published 11 November 2019

Academic Editor: Cristina Contreras

Copyright © 2019 Yih-Hsin Chang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Anti-inflammatory cytokine interleukin-4 (IL-4) promotes glucose tolerance and insulin sensitivity while reduces lipid deposits. However, the effects of IL-4 on energy metabolism in muscle, the largest insulin-targeting organ, remain obscure. The study aimed at addressing the roles of IL-4 in myocyte differentiation (myogenesis) and energy metabolism of muscle cells. Effects of IL-4 on myogenesis, and interaction between IL-4 and insulin on glucose metabolism of C2C12 myoblasts and the terminal differentiated myocytes were analyzed. IL-4 improved GLUT4 translocation and tended to elevate glucose uptake by boosting insulin signaling. In diabetic mice, transient and long-term IL-4 showed differential effects on insulin signaling and efficacy. The study provides evidence to address the roles of IL-4 in mediating whole-body muscle reservoir and glucose metabolism, as well as the interaction between immune responses and energy homeostasis. IL-4 has dual potential to act as an adjuvant therapeutic target for sarcopenia to preserve muscle mass and insulin resistance to improve insulin sensitivity, which implicates the regulation of immune system to the muscle differentiation and exercise performance.