Differential Expression of Inflammation-Related Genes in Down Syndrome Patients with or without Periodontal Disease

Table 3

Summary of the cell routes in which each of the statistically significant inflammation-related genes take part in the patients studied.

Gene	Cellular pathways	value	Fold change
TNFSF13B	(1) Cytokine-cytokine receptor interaction; (2) NF-kappa B signalling pathway; (3) Intestinal immune network for IgA production; (4) Rheumatoid arthritis	0.0448	-2
ITGB2	(1) Rap1 signalling pathway; (2) Phagosome; (3) Hippo signalling pathway; (4) Cell adhesion molecules (CAMs); (5) Complement and coagulation cascades; (6) Natural killer cell-mediated cytotoxicity; (7) Leukocyte transendothelial migration; (8) Regulation of actin cytoskeleton	0.0033	1.71
ANXA3	No data	0.0479	-2.22
ANXA5	(1) Release of platelet cytosolic components	0.016	-1.75