HPV-16 Infection Is Associated with a High Content of CD39 and CD73 Ectonucleotidases in Cervical Samples from Patients with CIN-1

Figure 3

Contents of CD39 and CD73 in cervical samples from CIN-1 patients and NDs. The presence of CD39 and CD73 solubilized in cervical samples was determined by ELISA as described in Methods. The contents of CD39 and CD73 in cervical samples from NDs free of HPV infection (black bars) and from CIN-1 patients, positive either for HPV-16 (HPV-16, white bars) or for coinfection with HPV-16 and other HPV genotypes (HPV-16+CI, diagonal lines), or from HPV patients negative for HPV-16 (HPV-16neg, horizontal lines) are shown. Data represent three independent experiments, and the are shown. indicates a significant difference () relative to the ND group. values were calculated using the Wilcoxon signed-rank test and Student’s -test.