Progressive Increase of Inflammatory CXCR4 and TNF-Alpha in the Dorsal Root Ganglia and Spinal Cord Maintains Peripheral and Central Sensitization to Diabetic Neuropathic Pain in Rats

<div>Persistent upregulation of correlative proinflammatory protein TNF-<i>α</i> and CXCR4 in the DRG in rats with DNP both at 2 weeks and at 5 weeks of diabetes. (a, b) Western blot showed the protein expression of CXCR4 and TNF-<i>α</i> in DRG at 2 and 5 weeks. (c, d) Quantitative analysis of CXCR4 and TNF-<i>α</i> in DRG at 2 weeks (c) and 5 weeks (d) of diabetes. 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Mediators of Inflammation

fig6

Figure 6

Figure 6: Progressive Increase of Inflammatory CXCR4 and TNF-Alpha in the Dorsal Root Ganglia and Spinal Cord Maintains Peripheral and Central Sensitization to Diabetic Neuropathic Pain in Rats 

Figure 6 | Progressive Increase of Inflammatory CXCR4 and TNF-Alpha in the Dorsal Root Ganglia and Spinal Cord Maintains Peripheral and Central Sensitization to Diabetic Neuropathic Pain in Rats 