Progressive Increase of Inflammatory CXCR4 and TNF-Alpha in the Dorsal Root Ganglia and Spinal Cord Maintains Peripheral and Central Sensitization to Diabetic Neuropathic Pain in Rats

Table 1

The analysis of mechanical allodynia and heat hyperalgesia in the diabetes group.

Statistics change	Von Frey (%)			Thermal (s)
Week	<40% ()	40%-78% ()	Total ()	<5.9 s ()	5.9-9.8 s ()	Total ()
1	5 (26.3%)	12 (63.1%)	17 (89.5%)	2 (10.5%)	14 (73.7%)	16 (84.2%)
2	2 (11%)	9 (47.4%)	11 (57.9%)	1 (5.3%)	9 (47.4%)	10 (52.6%)
3	0 (0%)	9 (47.4%)	9 (47.4%)	1 (5.3%)	13 (68.4%)	14 (73.6%)
4	0 (0%)	10 (52.6%)	10 (52.6%)	4 (21.1%)	6 (31.6%)	10 (52.6%)
5	0 (0%)	8 (42.1%)	8 (42.1%)	1 (5.3%)	9 (47.4%)	10 (52.6%)

The number statistics of diabetic neuropathic pain was analyzed after intravenous STZ rats in various time courses. 40% and 78% correspond to the average pain threshold at the+ first week minus or plus the SD of Von Frey test, respectively. Similarly, 5.9 s (second) and 8 s correspond to the average pain threshold at the first week minus or plus the SD of the Hargreaves test. deviation.