Curcumin Attenuates Asthmatic Airway Inflammation and Mucus Hypersecretion Involving a PPARγ-Dependent NF-κB Signaling Pathway In Vivo and In Vitro
Curcumin inhibited IL-4-induced NF-κB activation and DNA-binding activity in BEAS-2B cells. (a) Western blotting was performed to analyze the phosphorylation of NF-κB p65 in BEAS-2B cells; (b) DNA-binding activity of NF-κB p65 was measured by a TransAM™ p65 transcription factor ELISA kit. Quantitative data were presented as (). compared with control. compared with IL-4. compared with IL-4 + Cur + shRNA-PPARγ.