Curcumin Attenuates Asthmatic Airway Inflammation and Mucus Hypersecretion Involving a PPARγ-Dependent NF-κB Signaling Pathway In Vivo and In Vitro
Curcumin inhibited inflammatory cell counts and inflammatory mediators in BALF in OVA-induced chronic asthma. (a) TNF-α, IL-4, IL-5, and IL-13 in BALF were detected by ELISA. (b) Cells in BALF were collected, and cytospin preparations were made. Total cells, neutrophils, macrophages, eosinophils, and lymphocytes in BALF were measured; each bar represents the of 10 mice. compared with control. compared with OVA. compared with OVA + Cur + shRNA-PPARγ.