Curcumin Attenuates Asthmatic Airway Inflammation and Mucus Hypersecretion Involving a PPARγ-Dependent NF-κB Signaling Pathway In Vivo and In Vitro
Curcumin inhibited OVA-induced NF-κB activation and DNA-binding activity in the lung. (a) Western blotting was performed to analyze the phosphorylation of NF-κB p65 in the lung; (b) DNA-binding activity of NF-κB p65 was measured by a TransAM™ p65 transcription factor ELISA kit. Each bar represents the of 10 mice. compared with control. compared with OVA. compared with OVA + Cur + shRNA-PPARγ.