Curcumin Attenuates Asthmatic Airway Inflammation and Mucus Hypersecretion Involving a PPAR<i>γ</i>-Dependent NF-<i>κ</i>B Signaling Pathway In Vivo and In Vitro

<div>Curcumin inhibited OVA-induced NF-<i>κ</i>B activation and DNA-binding activity in the lung. (a) Western blotting was performed to analyze the phosphorylation of NF-<i>κ</i>B p65 in the lung; (b) DNA-binding activity of NF-<i>κ</i>B p65 was measured by a TransAM™ p65 transcription factor ELISA kit. 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96 71 90C59 80 50 67 49 57C48 45 52 36 66 23C80 9 123 -12 169 -12C221 -11 288 15 342 59C403 109 431 165 431 225C431 308 366 395 238 395C212 395 165 379 127 364L153 550Z"></path></g></svg> compared with OVA. <svg height="12.4111pt" id="M57" style="vertical-align:-0.6370001pt" version="1.1" viewbox="-0.0498162 -11.7741 49.9684 12.4111" width="49.9684pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M278 -108C276 -72 276 -41 276 6C276 132 289 239 307 279C282 327 275 360 273 404C334 402 369 393 402 372C420 379 445 401 457 422C445 442 420 464 402 471C369 449 334 441 273 439C276 506 281 532 311 583C297 609 275 635 252 647C231 635 207 609 194 583C223 532 229 506 232 439C171 442 135 450 103 471C84 463 60 441 49 422C60 401 84 379 103 372C135 393 171 402 232 404C230 360 224 327 199 279C217 239 228 132 228 6C229 -41 229 -72 227 -108H278Z"></path></g><g transform="matrix(.013,0,0,-0.013,5.129,0)"><path 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Mediators of Inflammation

fig7

Figure 7

Figure 7: Curcumin Attenuates Asthmatic Airway Inflammation and Mucus Hypersecretion Involving a PPAR<i>γ</i>-Dependent NF-<i>κ</i>B Signaling Pathway In Vivo and In Vitro 

Figure 7 | Curcumin Attenuates Asthmatic Airway Inflammation and Mucus Hypersecretion Involving a PPARγ-Dependent NF-κB Signaling Pathway In Vivo and In Vitro 