Thrombin Induces Secretion of Multiple Cytokines and Expression of Protease-Activated Receptors in Mouse Mast Cell Line

Figure 4

Expression of IκBα and phospho-IκBα in P815 cells at 0.5, 1, 2, and 4 h after treatment with 0.2 U/ml thrombin. The expression of phospho-IκBα in P815 cells increased obviously at 1, 2, and 4 h after incubation with 0.2 U/ml thrombin but not at the level of total IκBα. ANOVA was performed. Multiple comparisons were applied to compare the difference between each time. indicates that the difference between the control group and the diverse concentration of thrombin was statistically significant (; ; ).