Differences in cNOS/iNOS Activity during Resistance to Trypanosoma cruzi Infection in 5-Lipoxygenase Knockout Mice

Figure 7

Oxidative stress profile evaluated by tert-butyl hydroperoxide-initiated chemiluminescence on day 12 after T. cruzi infection. (a–d) Mice were infected with trypomastigote forms of T. cruzi (Y strain) and were treated or untreated with NOS inhibitors. (a) Uninfected mice and untreated T. cruzi-infected mice were used as controls. (b) AG: infected mice treated with aminoguanidine (50 mg/kg/day i.p.); (c) LN: infected mice treated with L-NAME (LN; 20 mg/kg/day i.p.); (d) AG+LN: infected mice treated with aminoguanidine (50 mg/kg/day i.p. plus L-NAME 20 mg/kg/day). animals in each group. Values represent the and are representative of two independent experiments .

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