Network of Mediators for Vascular Inflammation and Leakage Is Dysbalanced during Cytoreductive Surgery for Late-Stage Ovarian Cancer

Figure 5

Regulatory network of mediators and markers of vascular inflammation and leakage following CS. The figure shows the interactive association of the analyzed peptides. Proteins being upregulated following cytoreductive surgery (CS) are depicted in red, while those that were downregulated are shown in green. Peptides that are detectable but remained unchanged after 24 hrs are given in light red. Red arrows indicate positive regulation, while green arrows show suppression of expression. The dashed line indicates activation of the TIE2 receptor by its natural ligand ANGPT1.