Pattern Recognition Receptor-Mediated Chronic Inflammation in the Development and Progression of Obesity-Related Metabolic Diseases

Figure 1

Obesity-induced chronic tissue inflammation states in metabolic tissues. Chronic tissue inflammation induces a range of effects on adipose tissue, muscle, liver, pancreas, gastrointestinal tract, blood vessel, and hypothalamus. These inflammatory changes include the secretion of cytokines and chemokines, infiltration of immune cells, and activation of PRRs, which are the key points in the initiation and progression of obesity-related metabolic diseases.