Pattern Recognition Receptor-Mediated Chronic Inflammation in the Development and Progression of Obesity-Related Metabolic Diseases

Figure 2

Overview of PRRs in linking inflammation. As important players of the innate immune system, PRRs sense DAMPs from metabolic stress and/or tissue damage and PAMPs from gut microbiota and/or infection. Activation of PRRs induces a series of inflammatory responses and systemically mediates a chronic, low-grade inflammation, which promotes the pathogenesis of obesity-related metabolic diseases, such as insulin resistance, NAFLD, T2DM, and atherosclerosis.