IGF-1R Inhibition Suppresses Cell Proliferation and Increases Radiosensitivity in Nasopharyngeal Carcinoma Cells

<div>IGF-1R inhibition by linsitinib reverses the radioresistance in NPC cells. (a) Survival curves of parental CNE-2 cell lines and radioresistant CNE-2G cell lines. CNE-2 or CNE-2G cells were seeded in 6-well plates and further irradiated with various doses (0-10 Gy). The cells were cultured for 14 days to allow colony formation. (b) Verification of pIGF-1R expression levels by Western blotting. Serial dilution was used for cell lysate. (c) The clonogenic survival assay of CNE-2 and radioresistant CNE-2G cells; cells were treated with or without linsitinib (Lin., 0.4 <i>μ</i>M) and then irradiated with 4 Gy. Survival fraction was determined in the same way as in (a). 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Mediators of Inflammation

fig5

Figure 5

Figure 5: IGF-1R Inhibition Suppresses Cell Proliferation and Increases Radiosensitivity in Nasopharyngeal Carcinoma Cells 