Suberoylanilide Hydroxamic Acid Attenuates Autoimmune Arthritis by Suppressing Th17 Cells through NR1D1 Inhibition

<div>Effects of SAHA on T cells cultured <i>in vitro</i> under Treg to Th17 cell differentiation conditions. (a) Total splenocytes were extracted from the spleens of C57BL/6 mice and cultured under Treg-polarizing conditions for 3 days. The cells were converted to Th17-polarizing conditions with SAHA in fresh medium. The cells were subjected to flow cytometric analysis of Th17 or Treg cells. Representative results are shown. (b) Two days after inducing Th17 cells, the mRNA levels of IL-17 and IL-10 were measured. 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Mediators of Inflammation

fig6

Figure 6

Figure 6: Suberoylanilide Hydroxamic Acid Attenuates Autoimmune Arthritis by Suppressing Th17 Cells through NR1D1 Inhibition 