Figure 4: Quantification of histological findings—prophylactic. Histopathologic scores of synovial inflammation (a), chondrocyte death (b), cartilage erosion (c), bone erosion (d), and proteoglycan depletion (e) after PBS, RvE1, and anti-TNF treatment after induction of collagen-induced arthritis. One-way ANOVA followed by Tukey’s posttest was used to assess the differences among the groups. Differences were considered significant at . Statistically significant difference from the PBS and RvE1 groups.