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Figure 7: Synovial tissues from RA patients were stimulated with three different concentrations of RvE1 and with medium only (negative control) for 24 hours before supernatant collection. Six proinflammatory cytokines were measured: IL-1β (a), IL-6 (b), IL-8 (c), IL-10 (d), INF-γ (e), and TNF-α (f). One-way ANOVA followed by Tukey’s posttest was used to access the differences among the groups. Differences were considered significant at . No differences were found among the different dosages used for all the cytokines evaluated.