Dynamic Changes of Th1 Cytokines and the Clinical Significance of the IFN-γ/TNF-α Ratio in Acute Brucellosis

Table 1

Demographics, clinical data, and levels of Th1 cells and cytokines in brucellosis patients and healthy subjects.

	Brucellosis patients ()	Healthy subjects ()
Gender (M/F ratio)	35/16	11/6
Age (years)	46.7 (20-61)	39.0 (26-54)
Agglutination test	1 : 180 (1 : 50-1 : 400)	Negative
Peripheral blood cells
Leukocytes (WBC; ×10^9/L)	5.69 (1.61-10.4)	6.73 (3.97-8.88)
Lymphocytes (LY; ×10^9/L)	0.31 (0.10-0.68)	1.12 (0.41-1.77)
Platelets (PLT; ×10^9/L)	173.0 (30.0-459.0)	214.5 (157.1-276.5)
Alanine transaminase (ALT; U/L)	83.3 (2.90-676)	16 (9-23)
Aspartate transaminase (AST; U/L)	100.4 (13.7-736.5)	18 (9-31)
Erythrocyte sedimentation rate (ESR; mm/H)	40.6 (2.00-120)	Normal
C-reactive protein (CRP; mg/L)	48.9 (3.14-138)	Normal
IFN-γ (pg/mL)
TNF-α (pg/mL)
Th1 cells (%)

All values, except for age and agglutination, are expressed as average (range). Values for age and the agglutination test are expressed as median (range). vs. healthy subjects.