Dynamic Changes of Th1 Cytokines and the Clinical Significance of the IFN-γ/TNF-α Ratio in Acute Brucellosis
Table 1
Demographics, clinical data, and levels of Th1 cells and cytokines in brucellosis patients and healthy subjects.
Brucellosis patients ()
Healthy subjects ()
Gender (M/F ratio)
35/16
11/6
Age (years)
46.7 (20-61)
39.0 (26-54)
Agglutination test
1 : 180 (1 : 50-1 : 400)
Negative
Peripheral blood cells
Leukocytes (WBC; ×109/L)
5.69 (1.61-10.4)
6.73 (3.97-8.88)
Lymphocytes (LY; ×109/L)
0.31 (0.10-0.68)
1.12 (0.41-1.77)
Platelets (PLT; ×109/L)
173.0 (30.0-459.0)
214.5 (157.1-276.5)
Alanine transaminase (ALT; U/L)
83.3 (2.90-676)
16 (9-23)
Aspartate transaminase (AST; U/L)
100.4 (13.7-736.5)
18 (9-31)
Erythrocyte sedimentation rate (ESR; mm/H)
40.6 (2.00-120)
Normal
C-reactive protein (CRP; mg/L)
48.9 (3.14-138)
Normal
IFN-γ (pg/mL)
TNF-α (pg/mL)
Th1 cells (%)
All values, except for age and agglutination, are expressed as average (range). Values for age and the agglutination test are expressed as median (range). vs. healthy subjects.