PG102 Upregulates IL-37 through p38, ERK, and Smad3 Pathways in HaCaT Keratinocytes

<div>PG102 promotes colocalization of IL-37 and phospho-Smad3. Confocal microscopy of HaCaT cells treated with PG102 (1 mg/mL) for 24 hours. Localization of nuclei (DAPI), IL-37 (Alexa Fluor 488), and pSmad3 (Alexa Fluor 555) is shown. Colocalized proteins are shown in white arrowheads. Scale bar: 10 <i>μ</i>m.</div>

Mediators of Inflammation

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Figure 5

Figure 5: PG102 Upregulates IL-37 through p38, ERK, and Smad3 Pathways in HaCaT Keratinocytes 