Isorhamnetin Inhibits Liver Fibrosis by Reducing Autophagy and Inhibiting Extracellular Matrix Formation via the TGF-β1/Smad3 and TGF-β1/p38 MAPK Pathways
IH inhibited massive macrophage accumulation in liver tissues. (a) qPCR analysis of the F4/80 mRNA expression in liver tissues. Results are given as fold change over the control (vehicle or sham) group. (b) Representative immunostaining of F4/80 in different groups (brown indicates positive staining, original magnification: ×200 and ×400, scale bar: 100 μm). Data are presented as (, compared to the vehicle (sham) group, # compared to the CCl4 (BDL) group, and + compared to the CCl4 (BDL)+IH 10 mg/kg group).
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