Inhibition of Cerebral High-Mobility Group Box 1 Protein Attenuates Multiple Organ Damage and Improves T Cell-Mediated Immunity in Septic Rats

Figure 7

Effects of an ICV injection of BoxA on the survival rates of septic rats. The survival rates of septic rats were recorded at 12 h, 24 h, 36 h, 48 h, 72 h, 96 h, 120 h, 144 h, and 168 h after the onset of sepsis. Central administration of BoxA at a dose of 10 μg significantly improved the survival of septic rats in comparison with rats in the sepsis group (the sepsis+10 μg BoxA group vs. the sepsis group: 62% vs. 30%, , ). No significant improvement was found in survival rates when using a low dosage of BoxA injection in comparison with that of the sepsis group (the sepsis+1 μg BoxA group vs. the sepsis group: 34% vs. 30%, , ).