RIPK2-Mediated Autophagy and Negatively Regulated ROS-NLRP3 Inflammasome Signaling in GMCs Stimulated with High Glucose
Elevated ROS and IL-1β in SVs after HG exposure. HG enhanced ROS production compared to the NC and OP groups when cultured for 12 h (a) and 72 h (b). HG also induced a time-dependent increase in ROS production (c). The level of IL-1β increased in the HG group for 12 h (d) and 72 h (e), evaluated by ELISA. Moreover, HG caused an increase in IL-1β in a time-dependent manner (f). .
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