Mediators of Inflammation / 2019 / Article / Fig 3

Research Article

Systemic Inflammation Impairs Mood Function by Disrupting the Resting-State Functional Network in a Rat Animal Model Induced by Lipopolysaccharide Challenge

Figure 3

LPS challenge altered functional connectivity between the anterior cingulate cortex and retrosplenial cortex. (a) The group difference distribution map of the FC when the seed was set at the ACC (, corrected by family-wise error rate). Significantly increased FC are highlighted in the red-yellow heat bar scales. The ACC seed showed increased functional connectivity with the retrosplenial cortex compared with the control group. (b) The bar graph shows the mean FC values of RSC with the significant between-group difference extracted from the LPS and control groups. FC: functional connectivity, ACC: anterior cingulate cortex; RSC: retrosplenial cortex. vs. control group.

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