Circulating ANGPTL8 Is Associated with the Presence of Metabolic Syndrome and Insulin Resistance in Polycystic Ovary Syndrome Young Women
Table 1
Main clinical features and circulating betatrophin levels in study populations.
Group
PCOS
Controls
value
MetS
No-MetS
65
78
98
—
Age (yr)b
NS
BMI (kg/m2)a
25.9(23.2-30.4)▲▲
23.5(19.7-26.4)
20.0(18.6-21.3)
<0.001
FAT (%)
▲▲
<0.001
WHRb
0.89(0.83-0.93)▲▲
0.84(0.80-0.87)
0.78(0.75-0.84)
<0.001
SBP (mmHg)b
119(109-125)
114(107-120)
108(102-116)
<0.001
DBP (mmHg)
▲
<0.05
TG (mmol/L)a
2.30(1.66-3.08)▲▲
1.06(0.64-1.77)
0.80(0.59-1.29)
<0.001
TC (mmol/L)
▲
<0.001
HDL-C (mmol/L)b
1.20(1.04-1.25)▲▲
1.41(1.19-1.58)
1.17(0.99-1.43)
<0.001
LDL-C (mmol/L)
▲
<0.01
FFA (μmol/L)
NS
FBG (mmol/L)a
5.15(4.74-5.76)▲▲
4.81(4.43-5.05)
4.42(4.03-4.74)
<0.001
FIns (pmol/L)b
19.24 (13.3-28.3)▲▲
9.59(6.80-17.75)
7.02(6.10-8.45)
<0.001
HbA1c (%)b
5.30(5.10-5.65)
5.30(5.10-5.50)
5.20(5.00-5.30)
<0.001
HOMA-IRb
4.55(2.68-6.34)▲▲
2.05(1.52-3.55)
1.35(1.16-1.73)
<0.001
M-value (mg/kg/min)a
4.12(30.48-5.71)▲▲
5.91(4.95-8.77)
10.29(8.07-11.94)
<0.001
ADI (μg/mL)
▲▲
<0.001
ANGPTL8 (μg/L)
▲▲
<0.001
PRL (mIU/L)b
337.1(230.8-561.6)
381.6(216.8-490.0)
374.6(235.0-404.6)
NS
PROG (nmol/L)b
2.81(1.87-3.12)
2.81(2.18-3.12)
2.50(1.87-3.20)
NS
LH (IU/L)a
7.32(4.56-11.90)
10.80(6.21-15.09)
4.31(3.04-6.16)
<0.001
FSH (IU/L)a
7.60(6.10-8.63)
7.42(6.18-9.10)
7.80(6.73-9.26)
NS
TEST (nmol/L)b
2.99(1.95-3.86)
2.79(2.20-3.43)
1.65(1.21-2.29)
NS
E2 (pmol/L)b
212.9(126.6-280.8)
194.5(98.4-244.1)
183.5(119.6-255.1)
NS
DHEAS (μg/dL)b
202.9(163.3-149.5)
183.4.0(150.4-214.3)
182.1(141.9-217.0)
<0.05
SHBG (nmol/L)a
30.6(17.8-42.2)▲▲
40.6(24.2-75.2)
57.4(42.0-75.6)
<0.001
FAIa
9.45(4.83-16.96)▲
6.78(3.47-10.21)
2.59(1.80-4.97)
<0.001
BMI: body mass index; FAT%: body fat %; WHR: waist-to-hip ratio; SBP: systolic blood pressure; DBP: diastolic blood pressure; TG: triglyceride; TC: total cholesterol; HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol; FFA: free fatty acid; FBG: fasting blood glucose; FIns: fasting insulin; HOMA-IR: HOMA-insulin resistance index; -value: whole body glucose uptake rate; ADI: adiponectin; PRL: prolactin; PROG: progestogen; LH: luteinizing hormone; FSH: follicle-stimulating hormone; TEST: total testosterone; E2: estradiol; DHEAS: dehydroepiandrosterone sulfate; SHBG: sex hormone-binding globulin. FAI: free androgen index. Data are median (interquartile range) or frequency (percent). aLog transformed before analysis; bnonparametric test was used in comparisons between those groups. , compared with controls; ▲, compared with no MetS; , compared with the controls; ▲▲, compared with no MetS.
