Nonsurgical treatment (therapeutic) Atorvastatin Systemically (5 mg/kg in a volume of 0.5 mL) and locally (0.1 mg/kg in a volume of 0.05 mL) at a dose of 0.1 mg/kg in a volume of 0.05 mL
↗ alveolar bone area % ↗ VEGF ↘ MMP-9 ↘ alveolar bone and attachment loss Local application showed better results on periodontium healing
Atorvastatin increased the alveolar bone regeneration while decreasing the periodontal inflammation and attachment loss
Rats (female ovarectomized) EIP by ligatures Maxillary M1 and M2 bilaterally
Nonsurgical treatment (therapeutic) Simvastatin Local injection (0.8 mg/0.05 mL) Oral (25 mg/kg) For two months until euthanasia
↗ alveolar crest height (28% with local & oral and 27% with local) ↗ BV/TV ↗ trabecular thickness ↘ trabecular separation
Simvastatin reduced bone degradation when administered locally, systemically, or both locally and systemically together
The animals included in the studies are healthy unless stated otherwise. Treatment was considered (1) “preventative” when it started at least one day before the start of EIP/ACP induction, (ii) “protective” when it started the same day as that of EIP/ACP induction, and (iii) “therapeutic” when it started at least one day after the start of EIP/ACP induction.