Evidence That the Anti-Inflammatory Effect of Rubiadin-1-methyl Ether Has an Immunomodulatory Context

<div>Evaluation of Rubiadin-1-methyl ether cytotoxicity (RAW 264.7) (a) and calculated CC<sub>10</sub> (b) for this compound. B: cells pretreated with vehicle and stimulated with PBS; Rubiadin-1-methyl ether: cells pretreated with Rubiadin-1-methyl ether at doses at 1 to 300 <i>μ</i>M. Each bar represents the average survival of the macrophages in independent <span class="nowrap"><svg height="11.9218pt" id="M14" style="vertical-align:-3.16846pt" version="1.1" viewbox="-0.0498162 -8.75334 96.7821 11.9218" width="96.7821pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M380 106C343 72 306 56 265 56C195 56 116 112 115 248C235 252 361 262 377 265C396 269 400 277 400 297C400 374 333 449 250 449H249C198 449 144 421 103 376S37 269 37 201C37 88 109 -12 232 -12C263 -12 332 6 395 84L380 106ZM225 412C281 412 315 364 314 312C314 297 308 292 290 292C232 290 176 289 120 289C135 370 180 412 225 412Z"></path></g><g transform="matrix(.013,0,0,-0.013,5.525,0)"><path d="M474 0V26C414 34 401 43 364 100L267 248C300 297 324 332 345 358C381 400 394 405 455 411V437H272V411C316 406 323 401 305 370C287 337 267 306 247 276L188 369C169 397 173 405 215 411V437H16V411C71 404 83 396 114 348L201 212C171 167 144 127 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Mediators of Inflammation

fig2

Figure 2

Figure 2: Evidence That the Anti-Inflammatory Effect of Rubiadin-1-methyl Ether Has an Immunomodulatory Context 