Evidence That the Anti-Inflammatory Effect of Rubiadin-1-methyl Ether Has an Immunomodulatory Context

Figure 5

Effect of Rubiadin-1-methyl ether on total leukocyte counts (a), neutrophil counts (b), and exudation (c). S: healthy animals only treated with 0.9% sterile saline and vehicle (1% DMSO); LPS: (negative control) inflamed animals only stimulated with LPS (1 μg/mL) at intranasal route (i.n.); Dexa: (positive control) animals pretreated with Dexamethasone (5 mg/kg, p.o.) 1 h before LPS administration; Rubiadin-1-methyl ether: animals pretreated with Rubiadin-1-methyl ether at doses of 3, 10, and 30 mg/kg (p.o.) 1 h before LPS administration. The results were expressed as the ; ; , , and compared with the LPS group.

(a)

(b)

(c)