Mediators of Inflammation / 2019 / Article / Fig 1

Research Article

Repurposing of the Nootropic Drug Vinpocetine as an Analgesic and Anti-Inflammatory Agent: Evidence in a Mouse Model of Superoxide Anion-Triggered Inflammation

Figure 1

Vinpocetine decreases writhing, flinching of the paw, and time spent licking the paw induced by superoxide anion. The number of abdominal contortions over 20 min (a) after intraperitoneal injection of KO2 (1 mg/cavity). The number of paw flinches (b) and time spent licking the paw (c) were determined over 30 min after intraplantar injection of KO2 (30 μg/paw) ( vs. saline group; vs. vehicle (0 mg/kg) group; vs. 10 mg/kg, one-way ANOVA followed by Tukey’s posttest; mean ± SEM).