Association between Irisin, hs-CRP, and Metabolic Status in Children and Adolescents with Type 2 Diabetes Mellitus
Table 2
Anthropometric, metabolic, clinical, and inflammatory parameters for the T2DM and healthy control groups.
Parameter
T2DM ()
Healthy controls ()
value
Weight (kg)
68.4 (61.60-90.85)
34.90 (26.50-44.80)
<0.001
Height (m)
1.59 (1.55-1.66)
1.45 (1.33-1.60)
0.002
BMI (kg/m2)
27.8 (24.73-34.68)
17.70 (16.35-18.95)
<0.001
BMI%
96.4 (89.73-99.10)
54.15 (25.45-70.20)
<0.001
WC (cm)
<0.001
WC%
85.00 (50.00-93.75)
15 (10.00-25-00)
<0.001
HC (cm)
<0.001
WHI
0.081
W/ht
<0.001
SBP (mmHg)
112.00 (104.3-120.00)
98.00 (96.00-104.00)
<0.001
SBP%
58.00 (31.2-89.00)
39.00 (26.50-42.00)
0.027
DBP (mmHg)
67.50 (62.25-78.75)
64.00 (63.00-67.00)
0.249
DBP%
57.00 (43.25-90.75)
65 (53.00-67.50)
0.970
Glc (mg/dL)
114.5 (92.00-205.30)
84.00 (71.50-88.50)
<0.001
Serum insulin (mIU/L)
23.30 (10.63-30.93)
6.60 (4.83-7.98)
<0.001
HOMA-IR
8.35 (3.85-12.78)
1.20 (1.00-1.65)
<0.001
TC (mg/dL)
0.658
HDL-c (mg/dL)
37.50 (31.25-44.75)
50.50 (43.25-58.75)
<0.001
LDL-c (mg/dL)
0.001
TG (mg/dL)
157.00 (112.8-195.30)
87.50 (70.75-99.50)
<0.001
hs-CRP (mg/L)
0.006
TNF-α (pg/mL)
2.12 (1.92-2.51)
2.58 (2.25-2.85)
0.167
IL-6 (pg/mL)
3.38 (2.90-3.84)
4.13 (2.95-4.68)
0.104
Values are presented as median and interquartile range for nonparametric data and as mean and standard deviation for parametric data. BMI = body mass index; DBP = diastolic blood pressure; Glc = fasting glucose; HC = hip circumference; HDL-c = high-density lipoprotein cholesterol; hs-CRP = high sensitivity C-reactive protein; LDL = low-density lipoprotein cholesterol; HOMA-IR = homeostatic model assessment of insulin resistance; SBP = systolic blood pressure; T2DM = type 2 diabetes mellitus; TC = total cholesterol; TG = triglycerides; WC = waist circumference; WHI = waist-hip index; W/ht = waist-to-height ratio; % = percentile for age and gender.
