IL-17 Inversely Correlated with IL-10 via the STAT3 Gene in Pneumocystis-Infected Mice

Figure 6

STAT3 was in association with the interactions of IL-17 and IL-10. The experimental design for the antibody neutralization is shown (a). Representative flow dot plots and comparisons of B10 cells (CD19⁺IL-10⁺) (b), IL-10⁺ macrophages (F4/80⁺IL-10⁺) (c), and IL-10⁺ T cells (CD4⁺IL-10⁺) (d) in the lung from WT PCP mice that received PBS or anti-IL-17 antibody. Representative flow dot plots and comparisons of Th17 cells (CD4⁺IL-17⁺) (e) and IL-17⁺γδT cells (γδT⁺IL-17⁺) (f) in the lung from WT PCP mice that received PBS or anti-IL-10 antibody. STAT3 gene expression in the lung from WT PCP mice the received anti-IL-17, anti-IL-10, or PBS was examined by RT-PCR (g). , , and . Comparisons were evaluated by Student’s -test for two-group comparisons.