NLRP3 Inflammasome Is Involved in Calcium-Sensing Receptor-Induced Aortic Remodeling in SHRs
Calhex 231 attenuated NLRP3 inflammasome activation in the aortas of SHRs. (a) Immunohistochemistry was used to detect CaSR expression in the aortas of rats. Quantification of the relative CaSR protein levels in these arteries demonstrated that CaSR was increased in SHRs and decreased by antagonist of CaSR, bar = 50 μm, . (b) Western blot analysis of CaSR, NLRP3, ASC, and caspase 1. (c–g) Bar graphs showed the quantitative analyses of the proteins from B. (h) Representative western blot images of pro-IL-1β, IL-1β, and IL-18 in the aortas from experimental rats. (i–k) Quantitative analyses of proteins from in H. and vs. WKY; ,, and vs. SHRs.