NLRP3 Inflammasome Is Involved in Calcium-Sensing Receptor-Induced Aortic Remodeling in SHRs
Calhex 231 prevented the activation of NLRP3 inflammasome in VSMCs induced by Ang II. (a) Western blot images of CaSR and NLRP3 expression induced by Ang II in a time-dependent manner. (b) Quantification of the proteins from A. ,, and vs. 0 h, . (c) CaSR regulated NLRP3 inflammasome activation induced by Ang II. Western blot images of CaSR, NLRP3, ASC, and caspase 1. (d–h) Quantitative analyses of the proteins from C. ,, vs. control; and vs. Ang II.