NLRP3 Inflammasome Is Involved in Calcium-Sensing Receptor-Induced Aortic Remodeling in SHRs
Calhex 231 pretreatment inhibits Ang II-induced increase in cytosolic [Ca2+]i in VSMCs. (a) The cytosolic [Ca2+]i was stained with fluo3/AM and the levels of cytosolic [Ca2+]i were represented by intensity of fluorescence. Ang II induced an increase in cytosolic [Ca2+]i, which was prevented when pretreatment of Calhex 231 and BAPTA/AM, . (b) The schematic diagram of the mechanism of CaSR and NLRP3 inflammasome in vascular remodeling during hypertension. In VSMCs, cytosolic [Ca2+]i increase induced by CaSR triggers NLRP3 inflammasome activation; NLRP3 inflammasome induces cytokines IL-1β and IL-18 release, which leads to aortic fibrosis.