Neuroprotective Effects of Collagen-Glycosaminoglycan Matrix Implantation following Surgical Brain Injury

Figure 1

Evidence of a sustained decrease in inflammatory ED1⁺ cells (blue arrows) in the lesion boundary zone (LBZ) region of surgical brain lesions in the collagen-glycosaminoglycan matrix implantation following surgery-induced lesion cavity (L+CG) group compared with the surgery-induced lesion cavity (L) group. Representative microphotographs of immunofluorescence staining in representative brain sections from (a) the sham (SHAM) group, (b) the L group, and (c) the L+CG group on day 21. (d) Number of ED1⁺ cells in the LBZ from brain sections from the SHAM, L, and L+CG groups on days 7, 14, 21, and 28 after surgery. Data are presented as the (standard deviation). , , and vs. the SHAM group; , , and vs. the L+CG group. LBZ: lesion boundary zone; CAV: cavity; IMZ: intramatrix zone.

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