Relationship between Helicobacter pylori Infection and Plasmacytoid and Myeloid Dendritic Cells in Peripheral Blood and Gastric Mucosa of Children

Figure 5

Infiltration of dendritic cells into the gastric mucosa in H. pylori-infected and noninfected children. Representative images of CD11c, CD123, CD83, LAMP3, and CD86 staining in the lamina propria and epithelium in antral gastric mucosa biopsies from H. pylori-infected (Hp+) and noninfected (Hp-) children. Specific staining appears in brown, and the cell nuclei are counterstained with hematoxylin in blue. The arrows indicate positive staining. Visualization was performed by immunohistochemistry. Primary objectives, 20x and 40x (a). Scatter plots are showing differential densities (IRS (immunoreactive score)) of CD11c⁺, CD123⁺, CD83⁺, and CD86⁺ cells in gastric lamina propria mucosa (b) and CD123⁺, CD86⁺, and LAMP3⁺ cells in gastric epithelium (c) in H. pylori-infected children (Hp+: ) compared to noninfected children (Hp-: ). Data shown as individual raw data points, medians (horizontal line), and interquartile ranges (upper and lower whiskers). Statistically significant differences (Mann-Whitney test).

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